Clinicopathologic and prognostic significance of serum levels of cytokines in patients with advanced serous ovarian cancer prior to surgery.
- Author:
Xin ZHU
1
;
Li-sha YING
;
Shen-hua XU
;
Chi-hong ZHU
;
Jin-bo XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age Factors; Aged; Cystadenocarcinoma, Serous; blood; pathology; surgery; Cytokines; blood; Female; Follow-Up Studies; Humans; Interferon-gamma; blood; Interleukin-10; blood; Interleukin-2; blood; Interleukin-4; blood; Interleukin-5; blood; Kaplan-Meier Estimate; Lymphatic Metastasis; Menopause; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; blood; pathology; surgery; Preoperative Period; Prognosis; Proportional Hazards Models; Survival Rate; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Pathology 2010;39(10):666-670
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic and prognostic significance of serum levels of six cytokines (IFN-γ, TNF-α, IL-10, IL-5, IL-4, IL-2) in patients with advanced serous ovarian cancer prior to surgery.
METHODSThe serum levels of six cytokines were detected in 51 patients with advanced serous ovarian cancer and 46 healthy controls, using cytometric bead arrays.
RESULTSThe serum levels of IFN-γ (20.68±11.45), IL-2 (4.54±1.18), IL-4 (5.66±2.25), IL-5 (2.72±0.86) µg/L and IL-10 (5.93±7.92) µg/L were higher (P<0.01, P<0.05) and the serum level of TNF-α (7.53±8.47) was lower (P<0.01) in patients with advanced serous ovarian cancer than those in the healthy controls. The IFN-γ/IL-4 ratio (3.93±2.34) of the patients was lower than that of the controls (P<0.01). Kaplan-Meier analysis revealed that patient's age (P=0.016), menopausal status (P=0.001) and serum IL-10 level (P=0.010) correlated significantly with patient's survival. Cox regression analysis showed that serum IL-2 (P=0.045) and IL-10 levels (P=0.007) were the independent prognostic factors.
CONCLUSIONSPatients with advanced serous ovarian cancer have Th1/Th2 imbalance and immune function disturbance. The age of patients and menopausal status are important prognostic factors. IL-2 and IL-10 level are also independent predictors of survival.
