Clinicopathologic study of 7 cases of gastric T-cell lymphoma.
- Author:
Jian SUN
1
;
Zhao-Hui LU
;
Yu-Feng LUO
;
Qing LING
;
Jie CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; CD3 Complex; metabolism; CD5 Antigens; metabolism; CD56 Antigen; metabolism; CD8 Antigens; metabolism; Female; Gene Rearrangement, T-Lymphocyte; Humans; Ki-1 Antigen; metabolism; Lymphoma, T-Cell; genetics; metabolism; pathology; surgery; Male; Middle Aged; Mitochondrial Proton-Translocating ATPases; metabolism; RNA-Binding Proteins; metabolism; Retrospective Studies; Stomach Neoplasms; genetics; metabolism; pathology; surgery; Young Adult
- From: Chinese Journal of Pathology 2010;39(12):804-809
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic characteristics of gastric T-cell lymphoma.
METHODSThe clinicopathologic features of 7 cases of gastric T-cell lymphoma were retrospectively reviewed. Immunohistochemical study, T-cell receptor gene rearrangement analysis and evaluation of Epstein Barr virus (EBV) status were also performed.
RESULTSThe median age at onset of gastric T-cell lymphoma was 45 years. The male-to-female ratio was 6 to 1. The clinical information was available in 6 cases; and one of them had history of persistent diarrhea and 5 had hypoproteinemia. Histologically, 5 cases consisted of large lymphoma cells and the remaining 2 cases showed mainly medium-sized cells. Intraepithelial lymphoma cell infiltration was found in one case. The lymphoma cells of all cases were negative for CD20 and CD79a. CD3 and TIA-1 expression was noted in 6 of the 7 cases. CD5, βF-1 and CD30 were positive in 4 cases and CD4 was positive in 3 cases. In-situ hybridization for Epstein-Barr virus-encoded RNA was negative. Clonal T-cell receptor gene rearrangement was demonstrated in all cases.
CONCLUSIONGastric T-cell lymphoma is a rare type of malignant lymphoma, with distinctive clinicopathologic characteristics.
