Expression of PLAC1/CP1 genes in primary colorectal carcinoma and its clinical significance.
- Author:
Fang-Fang LIU
1
;
Dan-Hua SHEN
;
Shan WANG
;
Ying-Jiang YE
;
Qiu-Jing SONG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; surgery; Adult; Aged; Aged, 80 and over; Cell Nucleus; metabolism; Colorectal Neoplasms; metabolism; pathology; surgery; Cytoplasm; metabolism; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Pregnancy Proteins; metabolism; Sex Factors
- From: Chinese Journal of Pathology 2010;39(12):810-813
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression and significance of PLAC1/CP1 genes in patients with primary colorectal carcinoma.
METHODSThe expression of PLAC1/CP1 genes in 97 cases of colorectal carcinoma was studied using tissue chip technology and immunohistochemistry.
RESULTSThe rate of PLAC1/CP1 proteins expression in the cases studied was 56.7% (55/97), with 27.8% (27/97) being nuclear staining and 43.3% (42/97) being cytoplasmic staining. The percentage of expression was higher in women than in men (χ(2) = 6.567, P = 0.010). The expression in poorly differentiated colorectal carcinoma was significantly higher than that in the well or moderately differentiated carcinoma (χ(2) = 8.321, P = 0.016). The expression was also significantly higher in stage TNM III or IV tumors than in stage TNM I or II tumors (χ(2) = 18.726, P = 0.000). The rate was higher in cases with lymph node metastasis than in those with negative lymph nodes (χ(2) = 17.407, P = 0.000), and was higher as the number of metastasis increasing (χ(2) = 22.632, P = 0.000).
CONCLUSIONThe expression of PLAC1/CP1 genes correlates with various clinical and pathologic parameters. It carries prognostic significance and may represent a potential target for immunotherapy.
