Melanotic epithelioid clear cell tumor of kidney: report of three cases.
- Author:
Jun HOU
1
;
Jian-Fang XU
;
Yuan JI
;
Ying-Yong HOU
;
Yun-Shan TAN
;
Akesu SUJIE
;
Lei XU
;
Da-Ren SHI
Author Information
- Publication Type:Case Reports
- MeSH: Adolescent; Adult; Angiomyolipoma; metabolism; pathology; surgery; Carcinoma, Renal Cell; metabolism; pathology; surgery; Diagnosis, Differential; Epithelioid Cells; metabolism; pathology; Female; Follow-Up Studies; Humans; Kidney Neoplasms; metabolism; pathology; surgery; MART-1 Antigen; metabolism; Male; Melanoma-Specific Antigens; metabolism; Retrospective Studies
- From: Chinese Journal of Pathology 2010;39(12):825-829
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pathologic features and immunophenotype of 3 cases of melanotic epithelioid clear cell tumor of kidney.
METHODSMore than 2000 cases of renal tumors were retrospectively reviewed. Three cases of melanotic epithelioid clear cell tumor were identified. Immunohistochemical study was carried out using the paraffin-embedded tissue samples. Electron microscopy was also performed in 1 case.
RESULTSAmongst the 3 cases studied, the male-to-female ratio is 1:2. Histologically, 2 cases showed a clear cell carcinoma-like pattern. Papillary structures covered by clear cells and eosinophilic cells were observed in 1 case. Immunohistochemical study showed that the tumor cells in all cases expressed HMB 45. Two of them were also positive for Melan A. The staining for epithelial markers and S-100 protein was negative. Melanosomes were not identified by ultrastructural examination.
CONCLUSIONSMelanotic epithelioid clear cell tumor is a rarely seen neoplasm of kidney. There are some histologic overlaps with renal cell carcinoma, epithelioid angiomyolipoma and melanoma. Immunohistochemical study is useful in confirming the diagnosis. The tumor represents a morphologic variant of epithelioid angiomyolipoma.
