Factors associated with serum vitamin D levels in children with recurrent wheezing less than 3 years old.
10.4168/aard.2014.2.4.293
- Author:
Eun Jeong CHOI
1
;
Nu Ry BAG
;
Jin A JUNG
;
Dae Cheol KIM
;
Hye Sung AHN
;
Hyun Jin YUN
Author Information
1. Department of Pediatrics, Ilsin Christian Hospital, Busan, Korea. jinny198@hanmail.net
- Publication Type:Original Article
- Keywords:
Vitamin D;
Asthma;
Wheezing;
Young childhood
- MeSH:
Alkaline Phosphatase;
Aspartate Aminotransferases;
Asthma;
Blood Cell Count;
C-Reactive Protein;
Child*;
Eosinophils;
Humans;
Immunoglobulin A;
Immunoglobulin E;
Immunoglobulin G;
Pyruvic Acid;
Respiratory Sounds*;
Retrospective Studies;
Vitamin D*
- From:Allergy, Asthma & Respiratory Disease
2014;2(4):293-297
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the relationship between laboratory/clinical factors and vitamin D levels in recurrent wheezers less than 3 years old. METHODS: We retrospectively analyzed clinical data and laboratory factors (25-hydroxyvitamin D, complete blood count, C-reactive protein, glutamic oxaloacetic transaminase, glutamyl purovic transaminase, alkaline phosphatase [ALP], eosinophil counts, and serum IgE IgG, IgA, IgM) of 84 children less than 3 years who had experienced wheezing episodes at least 3 times. RESULTS: Children in the normal group (1.4+/-0.9 years) were younger than those in the deficient (2.2+/-1.2 years) and insuffient (2.3+/-1.0 years) groups (P=0.010). Glutamyl purovic transaminase were higher in the normal group (24.5+/-19.4 IU/L) than in the deficient (16.0+/-4.7 IU/L) and insufficient (15.3+/-4.5 IU/L) groups (P=0.009). ALP were higher in the deficient (791.4+/-180.8 IU/L) and insufficient (770.4+/-251.2 IU/L) groups than in the normal group (631.9+/-127.0 IU/L, P=0.034). Total IgE levels were higher in the deficient group (171.9+/-212.1 kU/L) than in the normal group (43.7+/-58.3 kU/L, P<0.05), and the rate of sensitization to aeroallergens was higher in the insufficient group (36.1%) than in the normal group (10%, P<0.05). CONCLUSION: Among children with recurrent wheezing less than 3 years old, low vitamin D levels may be associated with older age, total IgE, ALP level, glutamic pyruvate transaminase level, and rate of sensitization to aeroallergens.
