A IL-6R antagonist 2520A produced by a fungal species.
- Author:
Feng-chang ZHU
1
;
Rong JIANG
;
Yang ZHANG
;
Jian-bo WU
;
Yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; chemistry; isolation & purification; pharmacology; Antineoplastic Agents; chemistry; isolation & purification; pharmacology; Bacillus subtilis; drug effects; Cell Line, Tumor; Cell Survival; drug effects; Fermentation; Ferric Compounds; chemistry; isolation & purification; pharmacology; Ferrichrome; chemistry; isolation & purification; pharmacology; Humans; Mitosporic Fungi; chemistry; Molecular Structure; Peptides, Cyclic; chemistry; isolation & purification; pharmacology; Receptors, Interleukin-6; antagonists & inhibitors
- From: Acta Pharmaceutica Sinica 2006;41(7):662-665
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.
METHODSVarious column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.
RESULTSOne compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.
CONCLUSION2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.
