Inclusion of coenzyme Q10 with beta-cyclodextrin studied by polarography.
- Author:
Hai-ying YANG
1
;
Jun-feng SONG
Author Information
- Publication Type:Journal Article
- MeSH: Coenzymes; chemistry; Drug Compounding; methods; Light; Oxidation-Reduction; radiation effects; Polarography; methods; Ubiquinone; analogs & derivatives; chemistry; beta-Cyclodextrins; chemistry
- From: Acta Pharmaceutica Sinica 2006;41(7):671-674
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the inclusion of coenzyme Q10 with beta-cyclodextrin (beta-CD).
METHODSThe inclusion of the electroactive guest molecule coenzyme Q10 with the host molecule beta-CD was studied by the polarography. The change of the reduction peak current of the inclusion complex with time and the change of the peak potential of the inclusion complex with beta-CD concentration were examined. In order to study the photostability, the change of the reduction peak current of both coenzyme Q10 and coenzyme Q10-beta-CD inclusion complex with time were also examined under light, separately.
RESULTSIn 0.1 mol x L(-1) HAc/NaAc (pH 4.7) buffer-ethanol/water (60:40) medium, coenzyme Q10 was included with p-CD to form an 1:1 inclusion complex. The formation constant Kf was 1.26 x 10(4) L x mol(-1) the apparent formation rate constant was 6.64 x 10(-2) min(-1). The photodegradation apparent rate constant of coenzyme Q10 as 7.77 x 10(-3) min(-1) and that of the coenzyme Q10-beta-CD inclusion complex was 3.38 x 10(-3) min(-1).
CONCLUSIONThe inclusion of coenzyme Q10 with beta-CD took place. The stability of coenzyme Q10 to lights was improved in a certain degree due to the formation of the inclusion complex.
