Pharmacokinetics of doxorubicin alginate microspheres and evaluation of its hepatic arterial embolization in vivo.
- Author:
Dan LIU
1
;
Peng-cheng WANG
;
Xian-rong QI
;
Qiang ZOU
;
Ying-hua ZOU
;
Hong HONG
Author Information
- Publication Type:Journal Article
- MeSH: Alginates; chemistry; Angiography, Digital Subtraction; Animals; Antibiotics, Antineoplastic; administration & dosage; pharmacokinetics; Area Under Curve; Chemoembolization, Therapeutic; Doxorubicin; administration & dosage; blood; pharmacokinetics; Drug Carriers; Female; Hepatic Artery; diagnostic imaging; metabolism; Iodized Oil; chemistry; Liver; blood supply; diagnostic imaging; metabolism; Male; Microspheres; Particle Size; Swine; Swine, Miniature; Tomography, X-Ray Computed
- From: Acta Pharmaceutica Sinica 2006;41(8):778-783
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the pharmacokinetics of doxorubicin alginate microspheres (DOX-AM) in vivo after hepatic arterial embolization.
METHODSChina miniature pigs were chosen as the experimental animals. Transcatheter hepatic arterial chemoembolization (TACE) with DOX-AM (experimental group), lipiodol and DOX (DOX-lipiodol, control group 1), and infusion with DOX (control group 2) were performed after angiography and superselection of an intrahepatic branch of hepatic artery. After chemoembolization or infusion, the blood was collected at different time intervals. Drug concentration in plasma was measured by HLPC and the parameters of pharmacokinetics were calculated.
RESULTSThe values of T1/2, AUC, Cmax, and MRT of the DOX-AM were significantly different from those of control group 1 and control group 2. After embolization, the DOX-AM embolized in the vessel and still retained there at 8 weeks. The digital subtraction arteriography (DSA) and computerized tomography (CT) showed the reliable embolization results. The histological examination indicated that the liver damnifications were changed transitorily in all groups (P < 0.05) and were recovered within two weeks. The liver damnifications increased in following order: DOX < DOX-AM < DOX-lipiodol.
CONCLUSIONDOX-AM showed definite property of delayed release of drug in liver, and increased the retention time and concentration of DOX after embolization in vivo.
