Antitumor effects of nobiletin on Heps and its mechanism.
- Author:
Hong-quan ZHANG
1
;
Hui GE
;
Mei-ying CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; isolation & purification; pharmacology; Apoptosis; drug effects; Cell Line, Tumor; Cell Transformation, Neoplastic; drug effects; metabolism; pathology; Citrus; chemistry; Female; Flavones; isolation & purification; pharmacology; Humans; Interleukin-2; biosynthesis; Liver Neoplasms, Experimental; pathology; prevention & control; ultrastructure; Male; Mice; Mice, Inbred ICR; Plants, Medicinal; chemistry; T-Lymphocytes; drug effects; metabolism; pathology; Tumor Necrosis Factor-alpha; biosynthesis
- From: Acta Pharmaceutica Sinica 2006;41(8):797-800
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice.
METHODSModels of Heps tumor bearing mice were established. The inhibitory rates of tumor growth were calculated, the apoptosis morphology of tumor tissue was observed. The T lymphocyte transformation capacity was tested by MTT assay, the TNFalpha and IL-2 production were measured by LDH kits.
RESULTSNobiletin could significantly inhibit Heps tumor growth. The inhibitory rates were 42.14% - 65.09% (P < 0.01). The morphology of tumor tissues in nobiletin group had typical characters of necrosis and apoptosis through transmission electron microscope. Nobiletin could stimulate T lymphocyte transformation and the production of TNFalpha and IL-2.
CONCLUSIONNobiletin has obvious antitumor effect on Heps, the main mechanism is to enhance the cellular immune function and induce apoptosis of tumor tissue.
