Active constituents from Aloe arborescens as BACE inhibitors.
- Author:
Bo GAO
1
;
Chun-Suo YAO
;
Jin-Yun ZHOU
;
Ruo-Yun CHEN
;
Wei-Shuo FANG
Author Information
- Publication Type:Journal Article
- MeSH: Aloe; chemistry; Amyloid Precursor Protein Secretases; antagonists & inhibitors; metabolism; Anthraquinones; chemistry; isolation & purification; pharmacology; Aspartic Acid Endopeptidases; antagonists & inhibitors; metabolism; Chromones; chemistry; isolation & purification; pharmacology; Enzyme Inhibitors; chemistry; isolation & purification; pharmacology; Glucosides; chemistry; isolation & purification; pharmacology; Humans; Molecular Conformation; Molecular Structure; Plant Components, Aerial; chemistry; Plant Extracts; chemistry; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Pyrones; chemistry; isolation & purification; pharmacology
- From: Acta Pharmaceutica Sinica 2006;41(10):1000-1003
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo seek for new components as BACE inhibitors from Aloe arborescens.
METHODSThe chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
RESULTSEight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
CONCLUSIONCompound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
