Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates.
- Author:
Zhou ZHOU
1
;
Li-yuan JIANG
;
Yi-hua ZHANG
;
Hui JI
;
Yi SUN
;
Si-xun PENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aspirin; chemistry; Coumaric Acids; chemistry; Fibrinolytic Agents; chemical synthesis; chemistry; pharmacology; Models, Chemical; Molecular Structure; Nitrates; chemistry; Nitric Oxide Donors; chemistry; Oxadiazoles; chemistry; Platelet Aggregation; drug effects; Platelet Aggregation Inhibitors; chemical synthesis; chemistry; pharmacology; Rats
- From: Acta Pharmaceutica Sinica 2006;41(11):1050-1056
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo synthesize and study the antithrombotic activity of NO-donating aspirin derivatives.
METHODSFuroxans and nitrates were incorporated to aspirin via antioxidant ferulic acid as a linker, and the target compounds were screened for in vitro and in vivo inhibitory activities of platelet aggregation, and for inhibitory effect on A-V hypass thromhosis in rats.
RESULTSFourteen novel compounds I(1-14), were synthesized and their structures were confirmed Iy MS, IR, 1H NMR and elemental analysis. Biological screening results demonstrated that some tested compounds exhibited potential antithrombotic activ it.
CONCLUSIONAcetylsalicyl ferulic acid-coupling furoxans and nitrates might he used as a lead for further study.
