Serial Changes in Serum Eosinophil-associated Mediators between Atopic and Non-atopic Children after Mycoplasma pneumoniae pneumonia.
10.4168/aair.2014.6.5.428
- Author:
Joo Hwa KIM
1
;
Tae Shik CHO
;
Jin Hwa MOON
;
Chang Ryul KIM
;
Jae Won OH
Author Information
1. Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea. jaewonoh@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Eosinophil;
eosinophil cationic protein;
interleukin-5;
pneumonia;
Mycoplasma pneumoniae;
atopy
- MeSH:
Asthma;
Child*;
Enzyme-Linked Immunosorbent Assay;
Eosinophil Cationic Protein;
Eosinophils;
Follow-Up Studies;
Humans;
Interleukin-5;
Mycoplasma pneumoniae*;
Pneumonia*;
Pneumonia, Mycoplasma*
- From:Allergy, Asthma & Immunology Research
2014;6(5):428-433
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Mycoplasma pneumoniae pneumonia (MP) is associated with the exacerbation, timing, and onset of asthma. The goal of this study was to elucidate the impact of MP on eosinophil-related hyper-reactive amplification in atopic children. METHODS: We studied 48 patients with MP (26 atopic, 22 non-atopic), between 3 and 12 years of age. Serial changes in blood eosinophil counts, serum interleukin-5 (IL-5), and serum eosinophil cationic protein (ECP) levels were measured in atopic and non-atopic children with MP upon admission, recovery, and at 2 months post-recovery. Serum IL-5 and ECP levels were measured by enzyme-linked immunosorbent assays; eosinophil counts were measured using an autoanalyzer. RESULTS: Serial changes in serum IL-5, ECP, and total eosinophil counts were significantly higher in atopic patients, relative to non-atopic controls (P< or =0.001). Serum IL-5 and ECP levels were significantly higher in atopic patients at all three time points tested, while eosinophil counts were higher in the clinical recovery and follow-up phases, but not in the acute phase. Furthermore, among atopic patients, serum ECP levels were significantly higher in the recovery and follow-up phases than in the acute phase. CONCLUSIONS: The present study demonstrated significant differences in eosinophil counts, serum IL-5, and serum ECP levels between atopic and non-atopic children with MP at admission, recovery, and 2 months after clinical recovery. These outcomes are suggestive of eosinophil-related hyperreactivity in atopic children, with this status maintained for at least 2 months after MP.
