Effects of intracoronary autologous bone marrow mononuclear cells transplantation in patients with dilated cardiomyopathy
10.3321/j.issn:0253-3758.2008.12.009
- VernacularTitle:自体骨髓单个核细胞移植治疗扩张型心肌病疗效观察
- Author:
Yan CHEN
1
;
En-Min GAO
;
Chuan-Yu GAO
;
Yu XU
;
Ke-Jun HUANG
;
Zhen-Min NIU
;
Zhong-Yu ZHU
;
Hong-Hui YANG
;
Mu-Wei LI
Author Information
1. 河南省人民医院
- Keywords:
Cardiomyopathy,dilated;
Stem cell transplantation;
Treatment outcome
- From:
Chinese Journal of Cardiology
2008;36(12):1087-1091
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and effcacy of intracomnary autologous bone marrow mononuclear cells(BM-MNCs)transplantation in patients with dilated cardiomyopathy(DCM).Methods On top of standard therapy,DCM patients received BM-MNCs transplantation(n=71)or saline injection (n=187).The baseline clinical characteristics of two groups were comparable.Data on echocardiography,Holter,six-minute-walk test,cardiac SPECT and annual hospital days were obrained in all patients at baseline,1,3,6,12 and 24 months after transplantation.Results Six-minute-walk distance was significantly longer at one month[(345±76)m vs. (286±104)m,P<0.05]and thereafter(all P<0.05)in BM-MNCs group compared with saline group.Left ventricular ejection fraction(LVEF)at one month in BM-MNCs group was significantly higher compared with saline group[(41.5±9.4)%vs.(37.3± 6.6)%,P<0.05]and with pre-transplantation value[(41.5±9.4)%vs.(32.4±8.5)%,P<0.05] while LVEF was similar at 24 months after transplantation between the two groups[(43.6±6.3)%vs.(43.2±6.0)%.P>0.05 ].Three months after transplantation,the number of ischemic segments of BM-MNCs group wag significantly reduced compared with that of saline group(2.0±1.0 vs.3.1 ±1.4,P<0.05)and with baseline(2.0±1.0 vs.3.1±1.2,P<0.05)while the number of necrotic segments were similar in both groups during the follow-up.There were no significant difference in survival between two groups during 2 years follow·up(95.4%vs.94.9%,P>0.05)but the aflnual hospitalization days of BM-MNCs group was significantly lower than that of saline group[(23.6±13.4)d vs.(33.0±14.0)d,P>0.05].Conclusions Intracoronary transplantation of autologous BM.MNCs was safe and could increase LVEF and the six-minute-walk distance and reduce hospitalization days for patients witIl dilated cardiomyopathy.
