Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population
10.3760/cma.j.issn.0253-3758.2009.02.006
- VernacularTitle:新疆维吾尔族人心肌梗死与前列环素合酶基因单体型的相关性
- Author:
Yi-Tong MA
1
;
Xiang XIE
;
Zhen-Yan FU
;
Yi-Ning YANG
;
Xiang MA
;
Ying-Hong WANG
;
Bang-Dang CHEN
;
Fen LIU
Author Information
1. 新疆医科大学第一附属医院
- Keywords:
Myocardial infarction;
Polymorphism,single nucleotide
- From:
Chinese Journal of Cardiology
2009;37(2):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the polymorphisms and haplotypes of prostacyclin synthase gene with MI in Uigur patients in Xinjiang. Methods 210 patients with MI and 206 healthy control subjects were genotyped for 3 SNPs of the human prostacyelin synthase gene by polymerase chain reaction and restriction fragment length polymorphism. Results The genotype distributions of the control group and MI group were in the Hardy-Weinberg equilibrium (both P > 0.05 ). The frequency of CC of rs5629 in MI group was significantly higher than that in controls (71.42% vs. 61.65%, P=0.035).The frequency of A-C-T haplotype was significantly higher in the control group than that in the MI patients (4.01% vs. 0.60%, P=0.001 ). The frequency of C-T-T hapiotype was significantly higher in the MI patients than that in the controls (7.40% vs. 3.31%, P=0.011 ). Logistic regression analysis showed that, after adjusting hypertension, hyperlipemia and smoking, the CC genotype of rs5629(P=0.021, OR=1.665, 95% CI:1. 024-2.156) and the C-T-T haplotype (P=0.011, OR=1.876, 95% CI:1.410-3.171)was the independent risk factors for MI. Conclusion The CC genotype of rs5629 and the C-T-T haplotype of prostacyclin synthase gene are associated with MI but the A-C-T haplotype of prostacyelin synthase gene might be a protective factor of MI in Uignr population of Xinjiang.
