Relationship between serum resistin level and large arterial elasticity in patients with essential hypertension
10.3760/cma.j.issn.0253-3758.2009.02.009
- VernacularTitle:男性高血压患者睾酮与动脉顺应性关系的研究
- Author:
Xin-Li LI
1
;
Qiong XU
;
Min TONG
;
Hai-Feng ZHANG
;
Yan-Li ZHOU
;
Jun HUANG
Author Information
1. 南京医科大学附属第一医院
- Keywords:
Hypertersion;
Testosterone;
Compliance;
Arteries
- From:
Chinese Journal of Cardiology
2009;37(2):130-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between serum resistin concentration and large arterial elasticity in patients with essential hypertension (EH). Methods 271 recruited subjects were divided into the control group (n=134) and EH group (n=137). Blood pressure, waist circumference,hip, body mass index (BMI) were measured. Serum resistin concentration was assessed by enzyme immunoassay, fasting serum insulin and TNF-α were measured using radioimmunity kits. Insulin resistance was evaluated by insulin resistance index (HOMA-IR). Brachial ankle pulse wave velocity (baPWV) was tested by the full-automatic arteriosclerosis diagnostic instrument. Results (1) The serum resistin concentration, baPWV and TNF-α were significantly increased in EH group compared to the control group [(0.65±0.12) ng/ml vs (0.59±0.13) g/ml; (1513.24±182.30)cm/s vs (1301.69±151.15) cm/s;(5.69±1.98) ng/ml vs (3.83±2.38 ) ng/ml ; all P < 0.01 ]. (2) Pearson correlation analysis showed that resistin was positively correlated with baPWV, TNF-α. and HOMA-IR in EH group(r=0.219,r=0.212,r=0.183, P <0.05 respectively) ; partial correlation analysis revealed that resistin was positively correlated with baPWV and TNF-α(r=0.238, P < 0.01 ; r=0.207, P < 0.05 ), but not with HOMA-IR. (3) Multivariate regression analysis showed that SBP, age, TNF-α, resistin were risk factors of impaired baPWV in EH group ( R2 = 0.368, P < 0.01 ). Conclusion Large arterial elasticity was decreased in proportion to increasing serum resistin level in hypertensive patients.
