Effects of telmisartan on voltage-gated Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes

VernacularTitle:替米沙坦对电压依赖性的Kv1.3和Kv1.5通道电流阻断作用的实验研究
Author: Mu-Wei LI ¹ ; Xian-Pei WANG ; Chuan-Yu GAO ; An-Ruo ZOU
Author Information

1. 河南省人民医院
Keywords: Kv1.3 potassium channel; Kv1.5 potassium channel; Patch-clamp techniques; Telmisartan
From: Chinese Journal of Cardiology 2009;37(2):165-168
CountryChina
Language:Chinese
Abstract: Objective To observe the effects of telmisartan on Kv1.3 and Kv1.5 potassium channels expressed in Xenopus oocytes. Methods Kv1.3 and Kv1.5 potassium channel currents expressed in Xenopus oocytes were recorded and observed in the absence and presence of telmisartan using standard two-microelectrode voltage clamp techniques. Results Telmisartan resulted in a concentration- and voltage-dependent inhibition effect on Kv1.3 channel current (IC50 2.05 μmol/L) and on Kv1. 5 channel current (IC50 2.37 μmol/L). Conclusions Telmisartan blocks open-state Kv1.3 channel which could be one of the mechanisms related to its immunomodulatory and anti-atherosclerosis effect. Telmisartan also blocks open-state Kv1.5 channel which might partly account for its effect on reducing the incidence of atrial fibrillation.