Effects of montelukast on atherosderosis and monocyte chemoattractant protein-1 expression in a hypercholesterolemic rabbit model
10.3760/cma.j.issn.0253-3758.2009.03.014
- VernacularTitle:孟鲁司特对兔动脉粥样硬化的作用及其对单核细胞趋化蛋白-1表达的影响
- Author:
Song GE
1
;
De-Zhi LIU
;
Gnang-Yi ZHOU
;
Wei HU
;
Hong-Bing CHEN
;
Guo-Dong XIAO
;
Wu-Sheng ZHU
;
Ge-Lin XU
;
Xin-Feng LIU
Author Information
1. 南京大学临床学院南京军区南京总医院
- Keywords:
Atheroscleresis;
Receptors,leukotriene;
Antilipemic agents;
Chemokine CCL2
- From:
Chinese Journal of Cardiology
2009;37(3):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of montelukast on atherescleresis and monocyte chemoattractant protein-1 expression in a hyperchulesterolemic rabbit modeL Methods Thirty four male New Zealand white rabbits were randomized into four groups including normal control group (n=6), placebo in normal control group were fed a high cholesterol diet for 12 weeks. Serum lipids were measured at 0, 8 and 12 weeks after intervention. The intima/media ratio, percentages of macrophages or smooth muscle cells in intima and the expression of MCP-1 mRNA were examined. Results Atheresclerosis was evidenced in placebo group and atorvastatin or montelukast treatment significantly reduced neointima (0.32±0.12 and 0.34±0.10 vs. 1.12±0.36,P<0.05) and macrophage content [(9.8±4.6) % and(11.2±3.7) % vs. (34.6±8.8)%,P<0.05], increased SMC content [(18.6±6.9)% and(19.2±8.6)% vs. (5.2±2.3) %, P<0.05] and inhibited expression of MCP-1 mRNA (0.42±0.08 and 0.40±0.06 vs. 2.36±0.48 ,P<0.01). Montelukast had similar anti-atherogenetic effects as atorvastatin but had no influence on plasma lipids. Conclusions Montelukast could attenuate atherosclerosis in this hyperchulesterolemic rabbit model which might be attributed to its anti-inflammatory effects.
