Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure
10.3760/cma.j.issn.0253-3758.2009.03.015
- VernacularTitle:抗心肌纤维化治疗家兔慢性心力衰竭的实验研究
- Author:
Yan-Hong TANG
1
;
Ming-Wei BAO
;
Bo YANG
;
Yan ZHANG
;
Bing-Shan ZHANG
;
Qing ZHOU
;
Jin-Ling CHEN
;
Cong-Xin HUANG
Author Information
1. 武汉大学人民医院
- Keywords:
Heart failure,congestive;
Ventrieulur remodeling;
Curcumin
- From:
Chinese Journal of Cardiology
2009;37(3):262-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Curcumin on rabbits with chronic heart failure. Methods Heart failure was induced by combined aortic regurgitation and aortic stenosls in 20 New for 8 weeks, 10 sham operated rabbits served as controls (Con). Echocardiography was performed in all rabbits at baseline and 8 weeks later. Aortic diameter (AO), left ventricular ejection fraction (LVEF), left ventricular fractional shortening ( LVFS), left ventricular end-systolic dimension (LVDs), left ventricular end-diastolic dimension ( LVDd), left ventricular posterior wall thickness (LVPW) and interventricular septum thickness (IVS) were measured. Myocardial matrix metalloproteinase (MMP)-2 and MMP-9 expressions and fibrosis were determined by immunohistochemistry and Masaon staining respectively. Results Compared to baseline, LVEF and LVFS were significantly decreased, AO, LVDs, LVDd, LVPW, and IVS significantly increased at 8 weeks after operation in HF group hile these changes could be significantly attenuated in Curcumin treated rabbits. The protein expressions of MMP-2 and MMP-9 were significantly down-regulated in HF group and could be significantly up-regnlated by Curcumin treatment. The increased collagen deposition in HF group was also significantly reduced by Cureumin treatment. Conclusion Curcumin attenuated left ventricular dysfunction and remodeling by up-regulating MMPs expressions and reducing myocardial fibrosis.
