Expressions of interleukin-21 and interleukin-22 in Kimura's disease.
- Author:
Qingli CHEN
1
;
Lulu HU
1
;
Zhongcheng GONG
2
;
Email: GUMP0904@ALIYUN.COM.
;
Dwa SRIJANA
1
;
Xiaopeng YIN
1
;
Zhaoquan LIN
1
Author Information
- Publication Type:Journal Article
- MeSH: Angiolymphoid Hyperplasia with Eosinophilia; metabolism; Case-Control Studies; Eosinophils; Humans; Interleukins; metabolism; Leukocyte Count; Pruritus; metabolism; Recurrence
- From: Chinese Journal of Stomatology 2015;50(11):661-666
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of interleukin (IL)-21 (IL-21) and IL-22 in patients with Kimura's disease (KD).
METHODSExpressions of IL-21 and IL-22 were examined immunohistochemically in 36 patients with KD and 7 normal controls. The integral absorbance (IA) of the two groups was compared. Meanwhile, clinical data were reviewed.
RESULTSThe IA of IL-21 [M(Q): 1 373 418 (1 800 926)] and IL-22 [M(Q): 462 086(484 672)] in KD was significantly higher than those in normal controls [M(Q): 70 445(44 658), 51 599(71 241), P < 0.05]. The overexpression of IL-21 was significantly associated with pruritus (Z = -1.993, P < 0.05). Moreover, IL-21 was identified for disease recurrence (Z = -2.303, P < 0.05). There was a significant association between the expression of IL-22 and the number of affected sites (Z = -1.979, P < 0.05). In addition, IL-22 was significantly higher in the high-eosinophils group than in the low-eosinophils group (Z = -2.025, P < 0.05). There was no association between IL-21, IL-22 and age, gender, laterality, maximum size.
CONCLUSIONSIL-21 and IL-22 may be involved in the pathogenesis of KD.
