Expressions of interleukin-21 and interleukin-22 in Kimura's disease
10.3760/cma.j.issn.1002-0098.2015.11.005
- VernacularTitle:白介素21及22在木村病中的表达及意义
- Author:
Qingli CHEN
1
;
Lulu HU
;
Zhongcheng GONG
;
Dwa SRIJANA
;
Xiaopeng YIN
;
Zhaoquan LIN
Author Information
1. 新疆医科大学第一附属医院口腔颌面肿瘤外科
- Keywords:
Interleukins;
Angiolymphoid hyperplasia with eosinophilia;
Kimura's disease
- From:
Chinese Journal of Stomatology
2015;50(11):661-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of interleukin(IL)-21(IL-21) and IL-22 in patients with Kimura's disease(KD).Methods Expressions of IL-21 and IL-22 were examined immunohistochemically in 36 patients with KD and 7 normal controls.The integral absorbance(IA) of the two groups was compared.Meanwhile, clinical data were reviewed.Results The IA of IL-21[M(Q): 1 373 418 (1 800 926)] and IL-22[M(Q): 462 086(484 672)] in KD was significantly higher than those in normal controls[M(Q): 70 445(44 658), 51 599(71 241), P＜0.05].The overexpression of IL-21 was significantly associated with pruritus(Z=-1.993, P＜0.05).Moreover, IL-21 was identified for disease recurrence(Z=-2.303,P＜0.05).There was a significant association between the expression of IL-22 and the number of affected sites (Z=-1.979, P＜0.05).In addition, IL-22 was significantly higher in the high-eosinophils group than in the low-eosinophils group(Z=-2.025, P＜0.05).There was no association between IL-21, IL-22 and age,gender, laterality, maximum size.Conclusions IL-21 and IL-22 may be involved in the pathogenesis of KD.
