Plasma secreted phospholipase A2 in asthmatic children: correlation with leptin levels and exercise induced bronchoconstriction.
- Author:
Jueng Sup YOU
1
;
Won Bok CHOI
;
Yoon Young YI
;
Soo In JEONG
;
Joon Sup SONG
;
Seong YANG
;
Il Tae HWANG
;
Ha Baik LEE
;
Hey Sung BAEK
Author Information
- Publication Type:Original Article
- Keywords: Secreted phospholipase A2; Leptin; Exercise-induced bronchoconstriction; Asthma; Child
- MeSH: Asthma; Body Mass Index; Bronchoconstriction*; Child*; Forced Expiratory Volume; Humans; Inhalation; Leptin*; Phospholipases A2*; Plasma*; Respiratory Function Tests
- From:Allergy, Asthma & Respiratory Disease 2015;3(2):99-104
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Dysregulated cysteinyl leukotriene (CysLT) synthesis is prominent in exercise-induced bronchoconstriction (EIB). Secreted phospholipase A2 (sPLA2) plays a key regulatory role in the biosynthesis of CysLTs. We previously found that serum leptin levels correlate with (EIB) in children with asthma. The aim of this study was to address the relationship between plasma sPLA2/leptin levels and EIB. METHODS: Sixty-seven prepubertal children between the ages of 6 and 10 years were included in the study. They were asthmatics with EIB (n=25), asthmatics without EIB (n=21), and healthy subjects (n=21). We measured the plasma sPLA2 and leptin levels. We also performed pulmonary function tests at baseline, after bronchodilator inhalation, and after exercise. RESULTS: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in those without and control subjects. In addition, sPLA2 levels were significantly correlated with body mass index (Speraman correlation coefficient r=0.343, P=0.023) and leptin levels (partial correlation coefficient r=318, P=0.033). The maximum decrease in % forced expiratory volume in 1 second after exercise was significantly correlated with both PLA2 levels (r=0.301, P=0.041) and leptin levels (r=0.346, P=0.018). CONCLUSION: The sPLA2 and leptin levels were significantly higher in asthmatics with EIB than in asthmatics without EIB and control subjects. In addition, sPLA2 levels were significantly correlated with leptin levels and EIB in asthmatic children.
