Preparation of novel bioactive PCL bone tissue engineering scaffold.
- Author:
Qiang MA
1
;
Yingjun WANG
;
Huade ZHENG
;
Chengyun NING
;
Chunlin DENG
Author Information
1. Institute of Biomedical Materials Research, College of Materials Science and Engineering, South China University of Technology ,Guangzhou 510640, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemistry;
Bone Regeneration;
Guided Tissue Regeneration;
methods;
Humans;
Polyesters;
chemical synthesis;
Tissue Engineering;
Tissue Scaffolds;
chemistry
- From:
Journal of Biomedical Engineering
2009;26(3):550-565
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, porous PCL (poly (epsilon-caprolactone)) scaffolds were prepared through a melted extrusion manufacturing (MEM) machine, and carboxylate groups were formed on the surfaces of specimen by hydrolyzation with NaOH aqueous solutions. Apatite precursor was introduced on the surfaces of specimens with CaCl2 and K2 HPO4 under vacuum condition, and mineralization study was applied to these specimens. The results showed that the hydrophilicity of PCL surface was improved with the introduction of carboxylate groups, and the contact angle of surface was decreased to 26.52 degrees. A dense and uniform bone-like layer was confirmed to be formed on the surface of Ca-P treated specimens after mineralizing for less than 24 h in SBF by SEM and EDAX.
