Determination of content and entrapment efficiency of clindamycin phosphate liposome.
- Author:
Weihua ZHOU
1
;
Yangde ZHANG
;
Jiantai HE
Author Information
1. Institute of Biomedical Engineering of Centre South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
administration & dosage;
analysis;
Chromatography, High Pressure Liquid;
Clindamycin;
administration & dosage;
analogs & derivatives;
analysis;
Drug Carriers;
analysis;
Drug Compounding;
Drug Stability;
Liposomes;
administration & dosage;
analysis;
Technology, Pharmaceutical;
methods
- From:
Journal of Biomedical Engineering
2009;26(3):566-568
- CountryChina
- Language:Chinese
-
Abstract:
This study was conducted to prepare and determine the content and entrapment efficiency of Clindamycin Phosphate liposome. Evaporating and Ultrasound method was used for preparing Clindamycin Phosphate liposome. HPLC was used for determining the concentration and the entrapment efficiency of Clindamycin Phosphate liposome. The results indicated that Clindamycin Phosphate had a good linear relation in a range of 5.0-50.0 microg/ml. The entrapment efficiency of Clindamycin Phosphate liposome in three groups reached 52.26%, 50.13%, 53.75% respectively. Accordingly, the technique of preparing Clindamycin Phosphate liposome was noted to be feasible, and the method of quality control was shown simple and accurate.
