Study on Fibrovascular Ingrowth into the Intraocular Implant, Medpor(R).
- Author:
Sung Guan SOE
1
;
Young Il KIM
;
Sung Gyun SHIN
;
Boo Sup OUM
Author Information
1. Department of Ophthalmology, Busan Paik Hospital, The Inje University Medical College, Korea. seossg@hanmail.net
- Publication Type:Original Article
- Keywords:
Basic fibroblast growth factor;
Fibrovascular ingrowth;
Hyperbaric oxygen therapy;
polyethylene (Medpor(R)) implants
- MeSH:
Abdominal Muscles;
Fibroblast Growth Factor 2;
Hyperbaric Oxygenation;
Orbit;
Oxygen;
Rabbits
- From:Journal of the Korean Ophthalmological Society
2002;43(7):1310-1322
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We investigated the effects of bFGF/Sucralfate/Hydron suspension and hyperbaric oxygen on fibrovascular ingrowth into porous implants materials. METHODS: Eight rabbits underwent bilateral abdominal incision through which porous orbital disc-shaped implants were inserted between abdominal muscles. These implants were either uncoated or coated with suspension of bFGF/Sucralfate/Hydron. Hyperbaric oxygen therapy was performed on 4 selected rabbits for 5 days or 10 days. Implants were harvested after 3 days, 1 week, 2 weeks and 4 weeks. RESULTS: Enhanced fibrovascular ingrowth was shown in bFGF/Sucralfate/Hydron or hyperbaric oxygen treated implants. bFGF/Sucralfate/Hydron treated implants demonstrated more fibrovascularization than hyperbaric oxygen treated implants. CONCLUSIONS: Simultaneous therapy of bFGF/Sucralfate/Hydron and hyperbaric oxygen showed more fibrovascularization than separately treated implants.
