Determination of taxol in taxol injection using near infrared transmission spectroscopy.
- Author:
Ting XU
1
;
Min ZHOU
;
Leilei WANG
;
Liming YE
;
Cong CHEN
;
Yao TANG
;
Guo HUANG
;
Yanwei WU
Author Information
1. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
administration & dosage;
analysis;
Calibration;
Injections;
Paclitaxel;
administration & dosage;
analysis;
Spectroscopy, Near-Infrared;
methods
- From:
Journal of Biomedical Engineering
2009;26(5):982-984
- CountryChina
- Language:Chinese
-
Abstract:
The objective of this study was to develop a method for the determination of taxol injection using near infrared transmission spectroscopy, turning out redetermination for injection from hospital pharmacy before using. Near infrared spectra (NIR) in the range of 12 000 approximation 4 000cm(-1) were recorded for the taxol injection manufactured during recent 24 months with different time. Calibration models were established using the partial least squares (PLS). Comparing different spectra pretreatments methods, dimension and spectra range, The study showed that spectra information cab be extracted thoroughly by delete a line method with dimension 6, spectra range 9002.5 approximately 4597.7cm(-1) ,standard error of the calibration sets(SEC) 0.035 and standard error of the prediction sets(SEP) 0. 059. Percent of prediction sets sample is less than +/- 2%. Results indicate that near infrared transmission spectroscopy method can be used to rapidly analyze the frequent and important drugs from hospital pharmacy.
