A single nucleotide polymorphism in the matrix metalloproteinase 2 promoter is closely associated with high risk of nasopharyngeal carcinoma in Cantonese from southern China.
- Author:
Jian-Yong SHAO
1
;
Yun CAO
;
Xiao-Ping MIAO
;
Ma-Yan HUANG
;
Ling DENG
;
Jian-Jun HAO
;
Xiao-Man LIANG
;
Li-Fu HU
;
Ingemar ERNBERG
;
Dong-Xin LIN
;
Yi-Xin ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Carcinoma; Case-Control Studies; China; epidemiology; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Matrix Metalloproteinase 2; genetics; Middle Aged; Nasopharyngeal Neoplasms; epidemiology; genetics; pathology; Neoplasm Staging; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Risk Factors; Smoking; adverse effects
- From:Chinese Journal of Cancer 2011;30(9):620-626
- CountryChina
- Language:English
- Abstract: Matrix metalloproteinase 2 (MMP2) has been shown to play an important role in several steps of cancer development. The -1306C/T polymorphism of the MMP2 gene displays a strikingly lower promoter activity than the T allele, and the CC genotype in the MMP2 promoter has been reported to associate with the development of several cancers. To assess the contribution of the MMP2 -1306C/T polymorphism to the risk of nasopharyngeal carcinoma (NPC), we conducted a case-control study and analyzed MMP2 genotypes in 370 patients with NPC and 390 frequency-matched controls using real-time PCR-based TaqMan allele analysis. We found that subjects with the CC genotype had an increased risk (OR = 1.55, 95% CI = 1.05-2.27) of developing NPC compared to those with the CT or TT genotypes. Furthermore, we found that the risk of NPC was markedly increased in subjects who were smokers (OR = 15.04, 95% CI = 6.65-33.99), heavy smokers who smoked ≥ 20 pack-years (OR = 18.66, 95% CI = 7.67-45.38), or young (<60 years) at diagnosis (OR = 1.52, 95% CI = 1.01-2.29). Our results provide molecular epidemiological evidence that the MMP2 -1306C/T promoter polymorphism is associated with NPC risk, and this association is especially noteworthy in heavy smokers.
