Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population.
- Author:
Chang-Hu ZHOU
1
;
Jian-Ye WANG
;
Su-Yan CAO
;
Xiao-Hong SHI
;
Yao-Guang ZHANG
;
Ming LIU
;
Xin WANG
;
Jin HUANG
;
Yi-Ge YANG
;
Dong WEI
;
Ze YANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; Case-Control Studies; Chromosomes, Human, Pair 17; genetics; Gene Frequency; Genotype; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Polymorphism, Single Nucleotide; Prostatic Neoplasms; genetics; Risk Factors
- From:Chinese Journal of Cancer 2011;30(10):721-730
- CountryChina
- Language:English
- Abstract: In European populations, 7 single nucleotide polymorphisms (SNPs) on chromosome 17q, 3 SNPs on 17q12, and 4 SNPs on 17q24.3 were recently identified to be closely related to the risk of prostate cancer by a genome-wide association study. In Japanese populations, the correlation between 2 SNPs on 17q and the risk of prostate cancer and tumor aggressiveness was also confirmed by a large-scale experiment. However, whether 17q is associated with prostate cancer and its clinical manifestations in Chinese populations is still unknown. Therefore, we conducted a case-control study in a northern Chinese population and tested 2 SNPs, rs4430796 and rs1859962, on 17q in 124 prostate cancer patients and 111 controls using polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with sequencing. We analyzed the association of the 2 SNPs with the risk of prostate cancer as well as patients' lifestyles, onset ages, Gleason scores, PSA levels, and pathologic stages. We found a significant difference in the G allele of SNP rs1859962 (P = 0.035, OR = 1.51, 95% CI = 1.03-2.21) but not in the rs4430796 genotype frequency or allele frequency distribution between prostate cancer patients and the controls (P > 0.05). Neither of the SNPs was significantly associated with the onset age, Gleason score, PSA level, pathologic stage, or other clinical indicators of patients with prostate cancer (P > 0.05). Our results show that polymorphism of the G allele of SNP rs1859962 is associated with the risk of prostate cancer in a Chinese population.
