Role of ABC transporters in cancer chemotherapy.
- Author:
Yue-Li SUN
1
;
Atish PATEL
;
Priyank KUMAR
;
Zhe-Sheng CHEN
Author Information
- Publication Type:Editorial
- MeSH: ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters; antagonists & inhibitors; metabolism; ATP-Binding Cassette, Sub-Family B, Member 1; antagonists & inhibitors; metabolism; Antineoplastic Agents; therapeutic use; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Targeted Therapy; Multidrug Resistance-Associated Proteins; antagonists & inhibitors; metabolism; Nanomedicine; Neoplasm Proteins; antagonists & inhibitors; metabolism; Neoplasms; drug therapy; metabolism; Protein-Tyrosine Kinases; antagonists & inhibitors
- From:Chinese Journal of Cancer 2012;31(2):51-57
- CountryChina
- Language:English
- Abstract: Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR.
