Effect of Chinese drugs for Pi strengthening Shen benefiting on the immunity function of HIV patients' specific T cells.
- Author:
Wei-Hua LI
;
Chuan-Yun LI
;
Hui-Ping YAN
;
Xin ZHANG
;
Dan-Tong ZHAO
;
Xiu-Hui LI
- Publication Type:Journal Article
- MeSH: Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drugs, Chinese Herbal; pharmacology; Female; HIV Infections; drug therapy; immunology; Humans; Male; Middle Aged; T-Lymphocytes; drug effects; immunology; Viral Load
- From: Chinese Journal of Integrated Traditional and Western Medicine 2014;34(7):812-815
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of Chinese drugs for Pi strengthening Shen benefiting (CDPSSB) on the immunity function of HIV/AIDS patients' specific T cells.
METHODSTotally 20 patients were randomly recruited from the treated group [treated by CDPSSB combined highly active anti-retroviral therapy (HAART)] and 23 patients were randomly recruited from the control group (treated by HAART alone). All patients were follow-up infected persons form You'an Hospital between from June 2010 to June 2012. CD4+ T absolute counts and HIV viral load were detected. Meanwhile, HIV whole gene overlapping peptides were used as stimulating antigen. The response intensity of HIV specific T cells was detected in the two groups.
RESULTSThere was no statistical difference in CD4 T absolute counts or HIV viral load between the two groups (P > 0.05). The response intensity of HIV specific T cells was significantly enhanced in the treated group, when compared with the control group (P < 0.05). Along with elongation of treatment time (6, 12, 18, and 24 months) in the treated group, the response intensity of HIV specific T cells showed enhancing tendency, but there was no statistical difference among these time points (P > 0.05).
CONCLUSIONCDPSSB could enhance improve the immunity function of HIV specific T cells, which might be one of its mechanisms.