Study on the influence of biological characteristics to HIV/HCV co-infection among HIV infected illegal blood donors in China.
- Author:
Pin-liang PAN
1
;
Zhen LIU
;
Yong-hong ZHANG
;
Xiao-shan LONG
;
Hao WU
;
Yan JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Blood Donors; statistics & numerical data; CD4-Positive T-Lymphocytes; immunology; China; epidemiology; Female; HIV Infections; epidemiology; immunology; virology; HIV-1; classification; genetics; immunology; Hepatitis C; epidemiology; immunology; virology; Humans; Male; Phylogeny
- From: Chinese Journal of Epidemiology 2007;28(6):589-592
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of biological characteristics on HCV/HIV co-infection, including HIV-1 sequence distance, HIV-1 viral load and CD4+ count.
METHODSHIV-1 sequence distance was calculated by Clustal W and Phylip software while HIV-1 viral load being tested by NASBA and CD4+ count was tested using Epics XL of Coulter. Significance was determined by t-test using SPSS 12.0.
RESULTSThe mean HIV-1 genetic distances were 7.95% and 15.73% (P < 0.001) between those with HCV co-infection and those without. Their mean HIV-1 viral loads were 4.61 and 4.45 (P = 0.522) and their mean CD4I T counts were 308 and 251 (P = 0.161), respectively.
CONCLUSIONData showed that in the study group, the HIV/HCV co-infection had an influence on the HIV sequence distance, but did not have major impact on HIV-1 viral load and their mean CD4+ T count.
