Effects of hormone replacement therapy on platelet activation in postmenopausal women.
- Author:
Jian GU
1
;
Dongzi YANG
;
Liang'an WANG
;
Songmei YIN
;
Jianquan KUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Hormone Replacement Therapy; Humans; Middle Aged; Platelet Activation; drug effects; Postmenopause; physiology
- From: Chinese Medical Journal 2003;116(8):1134-1136
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo assess the effects of hormone replacement therapy (HRT) on platelet activation in postmenopausal women compared with premenopausal women.
METHODSThe expressions of CD41 and CD62P in fifteen postmenopausal women before and after HRT were detected using flow cytometry (FCM), with fifteen premenopausal women with a mean age of 47 years as controls.
RESULTSThe expressions of CD41 and CD62P in postmenopausal women were higher than those in the control group. CD62P(%), CD62P(I) and CD41 were reduced from 36.40 +/- 5.9, 37.75 +/- 5.8, and 470.11 +/- 74.0 to 27.97 +/- 5.6, 26.64 +/- 4.9, and 303.23 +/- 72.8 after six months of HRT (P < 0.05).
CONCLUSIONSPlatelet activation in postmenopausal women was higher than in premenopausal women and was reduced significantly after six months of HRT. HRT may have a favorable effect on reduction of platelet activity.
