Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization.
- Author:
Moubin LIN
1
;
Duan CAI
;
Mingde LUO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chromosome Aberrations; Chromosome Disorders; Female; Humans; Male; Middle Aged; Nucleic Acid Hybridization; Pancreatic Neoplasms; genetics
- From: Chinese Medical Journal 2003;116(8):1156-1160
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo identify genetic abnormalities in primary pancreatic carcinoma in humans.
METHODSComparative genomic hybridization (CGH) was used to investigate genomic imbalances in 27 cases of pancreatic carcinomas. Multiple deletions and gains were observed in all tumor specimens.
RESULTSLosses affecting chromosomes 9p, 17p, 4q and 6p and gains involving 8q, 7q, 3q and 1q were commonly observed.
CONCLUSIONSThere are multiple regions of chromosomes with changes copy number in pancreatic carcinoma. The altered chromosomal regions may contain several candidate genes which are involved in the development and progress of pancreatic carcinogenesis.
