Apolipoprotein E genotype in patients with Alzheimer's disease.
- Author:
Benyan LUO
1
;
Zhi CHEN
;
Yanyan ZHANG
;
Xiaoping PAN
;
Xia LI
;
Feng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alzheimer Disease; genetics; Apolipoproteins E; genetics; Female; Genotype; Humans; Male; Polymorphism, Genetic
- From: Chinese Medical Journal 2003;116(8):1220-1222
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD).
METHODSSingle nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing.
RESULTSThe single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05).
CONCLUSIONSThe 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.
