Allelopathic effect of artemisinin on green algae.
- Author:
Ye-Kuan WU
1
;
Ling YUAN
;
Jian-Guo HUANG
;
Long-Yun LI
Author Information
1. College of Natural Resources and Environment, Southwest University, Chongqing 400716, China.
- Publication Type:Journal Article
- MeSH:
Artemisinins;
pharmacology;
Chlorophyll;
metabolism;
Chlorophyta;
drug effects;
metabolism
- From:
China Journal of Chinese Materia Medica
2013;38(9):1349-1354
- CountryChina
- Language:Chinese
-
Abstract:
To study the growth effects of differing concentrations of artemisinin on green algae and to evaluate the ecological risk. The effects of artemisinin on the growth and the content change of chlorophyll, protein, oxygen, conductivity, SOD, CAT, MDA in Chlorella pyrenoidosa and Scenedesmus oblique were studied through 96 h toxicity tests. Artemisinin accelerated the growth of algae at a lower concentration ( <40 microg . L-1) with content increase of chlorophyll or protein and so on, and it inhibited the growth of algae at higher concentration ( >80 microg . L-1). The content of chlorophyll or protein in algae cells reduced with the increasing concentration of artemisinin, exhibiting the good concentration-effect relationship. SOD and CAT activity was stimulated at low concentrations ( <40 microg . L-1 ) and inhibited at high concentrations ( >80 microg . L- 1). However, MDA content increased significantly with the increase of concentration. According to the seven kinds of indicators changes, the time-response and dose-response suggested that the surfactant first hurt in Ch. pyrenoidosa was damaging membrane by changing membrane lipid molecules soluble. And primary mechanism on Chlorophyta cells might be related to the oxidation damage of lipid and other biological large molecules caused by artemisinin. The large-scale intensive planting of Artemisia annua may reduce the surrounding water productivity.
