Study on preparation of testosterone undecanoate ethosomes and its in vitro transdermal penetration.
- Author:
Shu MENG
1
;
Li-Qun YANG
;
Li-Ying MA
;
Jing GUO
;
Miao LI
;
Dan YANG
Author Information
1. Liaoning Institute of Family Planning, Shenyang 110031, China.
- Publication Type:Journal Article
- MeSH:
Administration, Cutaneous;
Animals;
Drug Delivery Systems;
Liposomes;
chemistry;
Mice;
Skin Absorption;
Testosterone;
administration & dosage;
analogs & derivatives;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(9):1371-1374
- CountryChina
- Language:Chinese
-
Abstract:
Ethosomes, as a new vector for transdermal drug delivery, could obviously improve the transdermal penetration of drugs. In this study, we prepared testosterone undecanoate ethosomes, with TU ethosomes as the basic remedy, to determine its appearance, particle size, entrapment efficiency (EE) and membrane fluidity. Meanwhile, a transdermal test was conducted in mice, in order to determine the permeability characteristics of ethosomes as a vector for transdermal drug delivery, and compare transdermal behaviors of TU ethosomes, liposomes and their ethanol solutions.
