Advance in studies on gut microbiota in de-glycosylation of traditional Chinese medicine glycosides.
- Author:
Sheng-Jie ZHANG
1
;
Jin-Rui GUO
;
An KANG
;
Liu-Qing DI
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. zsj114@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Bacteria;
metabolism;
Drugs, Chinese Herbal;
chemistry;
metabolism;
Gastrointestinal Tract;
metabolism;
microbiology;
Glycosides;
chemistry;
metabolism;
Glycosylation;
Humans;
Metagenome
- From:
China Journal of Chinese Materia Medica
2013;38(10):1459-1466
- CountryChina
- Language:Chinese
-
Abstract:
Glycosides are important active components in traditional Chinese medicine (TCM). Their pharmacological activity, pharmacokinetic characteristics and in vivo existence become hotspots of current studies. The metabolic pathways of these glycosides are de-glycosylation mainly mediated by gut microbiota. After glycosides were metabolized into aglycones, they could be absorbed more easily and show better pharmacological effects. In this article, we reviewed the main glycosidase in gut microbiota which helps metabolize TCM glycosides, relevant bacterial strains which generate glycosidase, as well as the de-glycosylated metabolic pathways of the representative glycosides, on the basis of gut microbiota's important roles in in vivo metabolism and efficacy of TCM glycosides. We also preliminarily solved problems in studies on de-glycosylation of TCM glycosides.
