Comparative study on toxicity of extracts from Phytolaccae Radix before and after being processed with vinegar.
- Author:
Le GONG
1
;
Hao WU
;
Hong-Li YU
;
Teng-Fei ZHAO
;
Qiu-Xiang XU
Author Information
- Publication Type:Journal Article
- MeSH: Acetic Acid; chemistry; Animals; Chemistry, Pharmaceutical; methods; Drugs, Chinese Herbal; isolation & purification; toxicity; Eye; drug effects; immunology; Male; Mice; Mice, Inbred ICR; Phytolacca; chemistry; Rabbits
- From: China Journal of Chinese Materia Medica 2013;38(10):1610-1613
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo extract and separate toxic components from Phytolaccae Radix, and to comare the changes in toxicity of Phytolaccae Radix before and after being processed with vinegar.
METHODThe mucous membrane irritation response, mouse peritoneal inflammation model and in vitro macrophages release NO model were applied to compared the changes in inflammatory toxicity of toxic components from Phytolaccae Radix before and after being processed with vinegar.
RESULTToxic components of Phytolacca Radix had significant inflammatory toxicity, which could cause conjunctival edema in rabbits, and increase of PGE2 and macrophages release NO content in peritoneal exudate in mice. After being processed with vinegar, they showed reduced irritation, which resulted in decrease of PGE2 and macrophages release NO content in peritoneal exudate in mice.
CONCLUSIONAfter being processed with vinegar, the toxicity of toxic components from Phytolacca Radix decreased obviously.
