Flavonoid glycosides from leaves of Turpinia arguta and their anti-inflammatory activity.
- Author:
Shuang-Gang MA
1
;
Shao-Peng YUAN
;
Qi HOU
;
Yong LI
;
Xia CHEN
;
Shi-Shan YU
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Inflammatory Agents;
chemistry;
pharmacology;
Cell Line;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Flavonoids;
chemistry;
pharmacology;
Glycosides;
chemistry;
pharmacology;
Magnoliopsida;
chemistry;
Mass Spectrometry;
Mice;
Molecular Structure;
Plant Leaves;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(11):1747-1750
- CountryChina
- Language:Chinese
-
Abstract:
Eight compounds were isolated from the leaves of Turpinia arguta by various chromatograhic techniques such as D101 macroporous resin, polyamide, Sephadex LH-20,and HPLC chromatography, and their structures were elucidated as rhoifolin (1), apigenin-7-O- [2"-O-alpha-L-rhamnopyranosyl-6"-O-alpha-L-rhamnopyranosyl] -beta-D-glucopyranoside (2), acacetin-7-O- [2"-O-alpha-L-rhamnopyranosyl-6"-O-beta-D-glucopyranosyl] -beta-D-glucopyranoside (3), acacetin-7-O- [2"-O-alpha-L-rhamnopyranosyl-6"-O-alpha-L-rhamnopyranosyl] -beta-D-glucopyranoside(neobudofficide, 4), luteolin-7-O-[2"-O-beta-D-glucopyranosyl] -beta-D-glucopyranoside (5), chrysoeiml-7-O-[2"-O-beta-D-glucopyranosyl] -beta-D-glucopyranoside (6), acacetin-7-O-alpha-L-rhamnopyranosyl-(1 --> 6) -O-beta-D-glucopyranoside (buddleoside, linarin, 7), and apigenin 6, 8-di-C-beta-D-glucopyranoside (8) on the basis of spectral data analysis. Compounds 3-8 were isolated from T. arguta for the first time. Compounds 2, 3 showed weak anti-inflammatory effect on LPS-stimulated RAW264.7 cell.
