Relationship between hyperuricemia and primary nephrotic syndrome in children.
- Author:
Huijie XIAO
1
;
Qian LI
;
Fang WANG
;
Yong YAO
;
Xuhui ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Child; Creatinine; blood; Humans; Hypertension; epidemiology; Hyperuricemia; epidemiology; Nephrotic Syndrome; epidemiology; Retrospective Studies; Uric Acid; blood
- From: Chinese Journal of Pediatrics 2014;52(11):859-862
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the relationship between hyperuricemia and primary nephrotic syndrome in childhood.
METHODA retrospective study was carried out in 107 children with primary nephrotic syndrome. The clinical data were analyzed with statistical methods to identify the related factors with hyperuricemia.
RESULTThe morbidity of hyperuricemia in children with primary nephrotic syndrome was 45% (48/107). Compared to those in normal serum uric acid group, the incidence of hypertension (33%, 16/48), serum triglyceride [2.59(1.62-3.87) mmol/L], creatinine [43.85(33.38-56.38)mmol/L], urea [6.11(3.77-8.40)mmol/L] and blood uric acid/creatinine ratio [9.30(7.03-12.72)] increased while creatinine clearance rate [141.74(103.57-160.97)ml/(min·1.73 (2))] decreased in hyperuricemia group.
CONCLUSIONHyperuricemia in children with primary nephrotic syndrome correlated with the increase of serum creatinine, urea and blood uric acid/creatinine ratio, the decrease of creatinine clearance rate and the occurance of hypertension.
