Modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene excretions.
- Author:
Qiang GAO
1
;
Zhi-yin XU
;
Shu-guang LI
;
Tai-guang JIN
;
Bo CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Control Groups; Genotype; Glutathione S-Transferase pi; genetics; Glutathione Transferase; genetics; Humans; Male; Middle Aged; Occupational Exposure; Polymorphism, Single Nucleotide; Pyrenes; analysis; Urinalysis; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(1):11-15
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-hydroxypyrene (1-OHP) excretions in workers under different exposure levels.
METHODSFour hundred and forty-seven occupationally exposed workers from two coking plants and 220 control workers from a wire rod plant were genotyped to analyze the modification of GSTM1, GSTT1 and GSTP1 gene polymorphisms on urinary 1-OHP excretions.
RESULTSThe urinary 1-OHP concentration in exposed group was much higher than that in control group (4.61 vs 0.34 µmol/mol Cr, P < 0.05). Occupational exposure levels and cigarette smoking were of the dominating factors affecting 1-OHP excretions in urine. After controlling potential confounders, decreased excretion of urinary 1-OHP was associated with GSTP1 I105V AG + GG genotype in coke oven workers (single-gene model, P = 0.012; multi-gene model, P = 0.011) and with GSTT1 null type in the analysis including all subjects (P = 0.055 in both single-gene and multi-gene models). GSTT1 and GSTP1 were interacted on the urinary concentrations of 1-OHP.
CONCLUSIONUrinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons.
