Influence of MDR1 gene C3435T on peripheral white blood cell counts in workers exposed to benzene.
- Author:
Jian-shu HUANG
1
;
Xin-jü ZHANG
;
Xiao XU
;
Ming GUAN
;
Yuan-ling ZHOU
;
Ling LÜ
;
He-jian ZOU
Author Information
- Publication Type:Journal Article
- MeSH: ATP Binding Cassette Transporter, Sub-Family B; ATP-Binding Cassette, Sub-Family B, Member 1; genetics; Adult; Benzene; adverse effects; Control Groups; Female; Genotype; Humans; Leukocyte Count; Male; Middle Aged; Occupational Exposure; Polymorphism, Single Nucleotide
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of MDR1 C3435T on the peripheral white blood cell counts in workers exposed to benzene.
METHODSOne hundred and twenty-one benzene-exposed workers and 110 healthy controls without benzene exposure were enrolled in this study. White blood cell counts influenced by the polymorphism of MDR1 gene were analyzed.
RESULTSThe frequency of MDR1 3435 C/C, C/T, T/T in healthy controls was 37.27%, 46.36%, 16.37%, respectively, and it was 38.84%, 41.33%, 19.83% in the benzene-exposed workers, respectively. The frequency of the MDR1 gene was also not significantly different between benzene exposed workers and controls. Subjects exposed to benzene with MDR1 3435 mutation genotype (T/T) had the significantly lower WBC [(5.46 ± 1.51) × 10(9)/L] than those carrying wild type (C/C) and heterozygous (C/T), whose WBC were (6.08 ± 1.28) × 10(9)/L (P = 0.044).
CONCLUSIONP-glycoprotein encoded by MDR1 gene may be implicated into the hematotoxicity of benzene. Subjects carrying MDR1 3435 T/T genotype may have a higher risk of benzene poisoning.
