Effect of tetradrine on electrophysilogic changes caused by rising of left ventricular preload in guinea pigs.
- Author:
Xing-xiang WANG
1
;
Jun-zhu CHEN
;
Long-xian CHENG
;
Li-Long ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; drug effects; Alkaloids; isolation & purification; pharmacology; Animals; Anti-Arrhythmia Agents; isolation & purification; pharmacology; Benzylisoquinolines; isolation & purification; pharmacology; Calcium Channel Blockers; pharmacology; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Guinea Pigs; Heart; physiology; In Vitro Techniques; Male; Plants, Medicinal; chemistry; Refractory Period, Electrophysiological; drug effects; Stephania tetrandra; chemistry; Streptomycin; pharmacology; Ventricular Function, Left; drug effects; Verapamil; pharmacology
- From: China Journal of Chinese Materia Medica 2003;28(11):1054-1056
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes of guinea pig heart electrophysiological properties caused by increasing left ventricular preload, and to assess the effects of tetradrine on these changes.
METHODWorking model preparation of guinea pig hearts in vitro was used, and the preload of left ventricle was increased by adjusting the prefusion pressure of left atria. The changes of heart electrophysiologic parameters including monophasic action potential duration (MAPD90), monophasic action potential amplitude (MAPA), effective refractory period (ERP) and ventricular fibrillation threshold (VFT) were observed before and after altering the preload of left ventricle, and compared in the absence and presence of tetradrine, streptomycin or verapamil.
RESULTThe rising of left ventricular preload led to shortening of MAPD90, ERP, and to descent of MAPA, VFT (all P<0.01). Both Tetradrine and streptomycin inhibited these changes of heart electrophysiologic parameters caused by elevation of left ventricular afterload (all P<0.01). In contrast, verapamil had no effects on the preload-related electrophysiological changes (all P>0.05).
CONCLUSIONElectrophysiologic changes caused by increasing left ventricular preload may be inhibited by tetrandrine, through inhibition of stretch-activated ion channels.
