Effect of guizhi tang and its active components on the fever induced by EP3 agonist.
- Author:
Cang-hai LI
1
;
Jun ZHOU
;
Hai-ru HUO
;
Xu-liang KANG
;
Ting-liang JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Acrolein; analogs & derivatives; isolation & purification; pharmacology; Analgesics, Non-Narcotic; isolation & purification; pharmacology; Animals; Body Temperature; drug effects; Cinnamates; isolation & purification; pharmacology; Dinoprostone; analogs & derivatives; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fever; chemically induced; physiopathology; Glucosides; isolation & purification; pharmacology; Male; Paeonia; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Receptors, Prostaglandin E; agonists; Receptors, Prostaglandin E, EP3 Subtype
- From: China Journal of Chinese Materia Medica 2003;28(11):1056-1060
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Guizhi Tang and its active components on the fever induced by EP3 receptor agonist sulprostone in rats.
METHODThe rise in body temperature evoked by a LCV(lateral cerebroventricle)-injection of sulprostone was compared with that of sulprostone induced-fever rats pretreated with Guizgi Tang and its active compounds, cinnamaldehyde, cinnamic acid and total glucosides of paeony.
RESULTPretreatments with Guizhi Tang and cinnamaldehyde inhibited the rise in body temperature induced by sulprostone, while cinnamic acid tended to augment the fever. The sulprostone-induced fever was blocked by an ip pretreatment of total glucosides of paeony even below the basement.
CONCLUSIONPresent data suggest that interruption with the down-stream events of EP3 receptor may contribute to the antipyretic action of Guizhi Tang, cinnamaldehyde and the total glucosides of paeony, while cinnamic acid may have no such effect.
