The effects of herb lithospermum extract on MCF-7 cell and estrogen and progestogen levels in mice.
- Author:
Wei WANG
1
;
Ping-ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Breast Neoplasms; metabolism; pathology; Cell Line, Tumor; Cell Proliferation; drug effects; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Estrogens; blood; Female; Humans; Hyperplasia; chemically induced; Lithospermum; chemistry; Mice; Mice, Inbred BALB C; Plants, Medicinal; chemistry; Progestins; blood; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Tamoxifen; adverse effects; Uterus; metabolism; pathology
- From: China Journal of Chinese Materia Medica 2003;28(11):1062-1067
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of lithospermum extract on MCF-7 cell and estrogen and progestogen levels in mice.
METHODCell growth curve and Western Blotting were used to do animal experiment.
RESULTLithospermum extract could inhibit the growth of MCF-7 cell. It could also inhibit the expression of ER and increase the expression of PR with large dose. After the mice were bred with Lithospermum, their serum estrogen and progestogen levels reduced, their uterus weight index decresed and uterus ER and PR levels increased. It could also improve the hyperplasia of uterus caused by tamoxifen.
CONCLUSIONLithospermum extract can inhibit the growth of MCF-7 cell and inhibit the level of estrogen and progestogen in mice.
