Effect of tea polyphenol on liver fibrosis in rats and related mechanism.
- Author:
Xing-guo ZHANG
1
;
Chao-hui YU
;
Yu-e QING
;
Yu ZHANG
;
Shao-hua CHEN
;
You-ming LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Collagen; metabolism; Endotoxins; blood; Female; Flavonoids; isolation & purification; pharmacology; Glutathione; blood; Liver; metabolism; pathology; Liver Cirrhosis; blood; etiology; metabolism; Liver Diseases, Alcoholic; complications; Male; Malondialdehyde; blood; Phenols; isolation & purification; pharmacology; Polyphenols; Protective Agents; isolation & purification; pharmacology; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; blood; Tea; chemistry
- From: China Journal of Chinese Materia Medica 2003;28(11):1070-1072
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of tea polyphenol (TP)'s on liver fibrosis in rats and its possible mechanism.
METHODRats were divided into 5 groups, 4 groups of which were stomach perfused with alcohol resulting in alcoholic liver fibrosis, and 3 groups of which were stomach perfused with TP simultaneously. Another group was normal control one. Histological change of rat liver was investigated and quantitative analysis was made in 24 weeks, and rat liver anti-oxidation index and serum endotoxin were determined at the same time.
RESULTLiver fibrosis in TP group was slight, and anti-oxidize index and endotoxin level were markedly improved in comparison with those of alcohol groups.
CONCLUSIONTea polyphenol can protect hepatocytes from fibrosis. Its mechanism is possibly due to cleaning up overfull lipid per-oxidation and reducing the level of endotoxin.
