Anti-mutagenesis effects of total flavonoids of Astragalus.
- Author:
De-qing WANG
1
;
Ya-ping TIAN
;
Shu-zhen SONG
;
Ling WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antimutagenic Agents; isolation & purification; pharmacology; Astragalus membranaceus; chemistry; Cells, Cultured; Chromosome Aberrations; drug effects; Cricetinae; Cricetulus; Flavonoids; isolation & purification; pharmacology; Male; Mice; Micronucleus Tests; Mutagenesis; drug effects; Plants, Medicinal; chemistry; Testis; cytology; drug effects
- From: China Journal of Chinese Materia Medica 2003;28(12):1164-1167
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the anti-mutagenic action of the total flavonoids of Astragalus (TFA).
METHODThree groups of concentrations of TFA and one inducer group were used. The anti-mutagenic action of TFA was studied by experiments in vitro and in vivo including miconucleolus assay, semen teraogenesis test and gene mutagenesis of V79/HGPRT.
RESULTTFA did not affect the weight of the mice during the experiment period. The high concentration of TFA could significantly reduce cyclohophamide-induced miconucleolus number and gene mutagenesis of V79/HGPRT compared with inducer group. However, TFA did not make statistic change in the semen teraogenesis induced by mitomycin C.
CONCLUSIONTFA has antimutagenesis effect.
