Study on the anticancer activities (in vivo) of the extract from Citrus reticulata Blanco and its influence on sarcoma-180 cells cycle.
- Author:
Shi-hui QIAN
1
;
Yi-xian WANG
;
Nian-yun YANG
;
Li-hong YUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents, Phytogenic; isolation & purification; pharmacology; Apoptosis; drug effects; Carcinoma, Ehrlich Tumor; drug therapy; pathology; Cell Cycle; drug effects; Cell Line, Tumor; Citrus; chemistry; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Fruit; chemistry; Liver Neoplasms, Experimental; drug therapy; pathology; Male; Mice; Neoplasm Transplantation; Plants, Medicinal; chemistry; Sarcoma 180; drug therapy; pathology
- From: China Journal of Chinese Materia Medica 2003;28(12):1167-1170
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anticancer activity of the extract from Citrus reticulata in vivo.
METHODAnticancer activities were tested with tumor model in vivo (Sarcoma-180 cells, Heps cells, EAC cells implanted in mice).
RESULTThe extract from Citrus reticulata showed marked anticancer activities on Sarcoma-180 cells and Heps cells implanted in mice, had no marked anticancer activities on EAC cells implanted in mice and induced apoptosis of Sarcoma-180 cell.
CONCLUSIONThe extract from Citrus reticulata will have promising prospects as an anticancer Chinese medicine, but further studies will be needed.
