Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat.
- Author:
Yuan-jing WANG
1
;
An-hong JIANG
;
Qin-mao WANG
;
Mei BAI
;
Ke-long MA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; blood; etiology; Endothelin-1; blood; Female; Infarction, Middle Cerebral Artery; complications; Insulin; blood; Insulin Resistance; Male; Neuroprotective Agents; pharmacology; Pyrazines; pharmacology; Random Allocation; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; blood; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2003;28(12):1181-1183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat.
METHODModels of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-alpha), plasma endothelin-1 (ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were observed 2 weeks after the ischemia.
RESULTLigustrazine could significantly reduce serum insulin (P < 0.01), the content of plasma ET-1 (P < 0.01) and serum TNF-alpha (P < 0.01), the activity of brain tissue NO and NOS (P < 0.01). The drug also increased insulin sensitivity indexes (ISI).
CONCLUSIONThe protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.
