Study on the production condition of extraction in combination hydrolysis in situ for isolating diosgenin.
- Author:
Jun WANG
1
;
Jun CHEN
;
Ke-di YANG
;
Liu-qing YANG
;
Zhen OUYANG
Author Information
- Publication Type:Journal Article
- MeSH: Dioscorea; chemistry; Diosgenin; isolation & purification; Hydrolysis; Pressure; Sulfuric Acids; Technology, Pharmaceutical; methods; Temperature; Time Factors
- From: China Journal of Chinese Materia Medica 2003;28(10):934-937
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the production technology of extraction in combination hydrolysis in situ for isolating diosgenin from Dioscorea nipponica by orthogonal design.
METHODThe optimum production conditions were investigated with the recovery of diosgenin as an index by extraction in combination hydrolysis in situ, and were compared with the traditional method.
RESULTExtraction in combination hydrolysis in situ conducted in 1.5 mol x L(-1) sulfuric acid of water containing 75% isopropanol at 100 degrees C for 4.5 h could get higher recovery of diosgenin than traditional methods.
CONCLUSIONThis production technology can get higher recovery of diosgenin, and it is simple, time and money saving.
