Protective effects of Cleistocalyx operculatus on lipid peroxidation and trauma of neuronal cells.
- Author:
Yan-hua LU
1
;
Chang-bin DU
;
Zi-bin WU
;
Chun-lin YE
;
Jian-wen LIU
;
Dong-zhi WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; pharmacology; Cytoprotection; drug effects; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; isolation & purification; pharmacology; Hydrogen Peroxide; antagonists & inhibitors; toxicity; Lipid Peroxidation; drug effects; Male; Mice; Microsomes, Liver; metabolism; Myrtaceae; chemistry; Neuroprotective Agents; pharmacology; PC12 Cells; Plants, Medicinal; chemistry; Rats
- From: China Journal of Chinese Materia Medica 2003;28(10):964-966
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the protective effects of Cleistocalyx operculatus on lipid peroxidation in rat liver microsomes and on the trauma of PC12 cells induced by H2O2.
METHODThe mouse liver homogenate lipid peroxidation assay and PC12 Cell culture and Cell viability (MTT assay) were applied.
RESULTCleistocalyx operculatus showed strong protective effects on lipid peroxidation in rat liver microsomes in a dose-dependent manner and exhibited potent protective effects on the trauma of PC12 cells induced by H2O2 (200 micromol x L(-1)) when the concentration reached 1.00 g x L(-1).
CONCLUSIONCleistocalyx operculatus may be used as antioxidant to prevent or delay the pathogenesis of neural cell diseases.
